100 patients with primary osteoarthritis who were scheduled to undergo unilateral cemented total knee arthroplasty were randomized to receive either placebo or intravenous tranexamic acid 10 minutes prior to surgery, 3 hours after surgery, and orally for 5 days after surgery. Patients who received tranexamic acid displayed significantly less blood loss, hemoglobin loss, and required significantly less blood transfusion in comparison to patients who received placebo. Additionally, no changes were observed in symptomatic thromboembolic events.
Clin Orthop Relat Res; 2011; 469(10): 2874-2880
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